If you want to configure Nginx for multisite, the first step would be to review the following step by step process - http://rtcamp.com/tutorials/nginx-wordpress-multisite-subdomains-domain-mapping-wp-super-cache/ The above link deals with the configuration changes that need to be completed in the Nginx config file and it would work fine in a CentOS environment as well. If you want to make the rewrite rules created at .htaccess to work with Nginx , you may also need to convert it which can be done by following the below link which converts .htaccess rules to Nginx format. http://winginx.com/htaccess